Friday May 12, to Sunday May 14, 2006
Wolstein Research Building Auditorium, Cleveland , Ohio
Schedule
Friday, May 12, 3.30 - 6.30 pm
3.30 pm Welcome and Introduction by Paul Carey (CCSB Director)
Opening Remarks: George Stark, (Dep. of Genetics, Case Western Reserve University , formerly Chair of the CCF Lerner Research Institute)
4pm - 6.40 pm
• Session 1: Experimental and computational aspects of conformational
change/dynamics
Chair: Frank Sönnichsen
- 4.00-4.25 Erik Zuiderweg (Univ. Michigan )
"NMR: changing structural biology from still pictures to dynamical movies" - 4.30-4.55 Mark Rance (Univ. Cincinatti)
" Studies of Sidechain Dynamics in Calbindin D9k" - 5.00-5.15 Coffee Break
- 5.15-5.35 Matthias Buck (CCSB)
"NMR studies of a plexin domain with/without Rac1 GTPase" - 5.35-6.05 Rafael Brüschweiler ( Florida )
"Computationally enhanced analysis of NMR spin relaxation" - 6.05-6.35 Art Palmer ( Columbia )
"Protein motions in folding, binding, and catalysis"
6.40 pm - 9.30 pm
• Poster session & Barbecue dinner at the Wolstein courtyard
Saturday, May 13, 8.30 am - 12.30 pm
• 8.30: Remarks by
Dr. Pamela Davies,Vice Dean of Research, Case School of Medicine, and
Dr. Paul diCorleto, Chair of CCF Lerner Research Institute
• Session 2 : Recent Developments in NMR methodology and technology
Chair: Michael Weiss
- 9.00-9.25 Michael Summers (Univ. Maryland )
"New insights into retroviral genome packaging and assembly by NMR" - 9.30-9.55 Kwaku Dayie (CCSB)
"Large RNA macromolecular complexes by NMR: Prospects and Progress" - 10.00-10.25 Juli Feigon (UCLA)
"Structure and Function of Human Telomerase"
Break (15 mins)
Chair: Kwaku Dayie
- 10.45-11.10 Wolfgang Bermel (Rheinstetten)
"C13 detected experiments for studying proteins" - 11.15-11.40 Thomas Szyperski (SUNY Buffalo)
" GFT Projection NMR spectrocopy" - 11.45-12.30 Symposium Speaker: Kurt Wüthrich (ETH Zürich and Scripps Inst.)
"Recent advances in solution NMR for small and large proteins"
Lunch (55 mins)
Saturday, May 13, 1.30-5.00 pm
• Session 3 : Frontiers in NMR applications
Chair: Matthias Buck
- 1.30-2.10 Gerhard Wagner (Harvard)
"How can the ribosome be convinced to make protein, and how can it be tricked" - 2.15-2.40 Jun Qin (CCSB)
"NMR studies of supramolecular complexes involved in focal
adhesions" - 2.45-3.10 Brian Sykes ( Alberta )
"Role of Dynamics in Calcium Regulation of Striated Muscle"
Break (15 mins)
Chair: Tom Gerken
- 3.30-3.55 Sharon Campbell (UNC)
"NMR studies of Vinculin and Focal Adhesion Kinase: Two Cell Adhesion Proteins with Opposing Functions" - 4.00-4.25 Michael Weiss (CCSB)
"NMR Studies of Sex Determination" - 4.30-4.55 David Cowburn, New York Structural Biology Center
"Defining protein-protein interfaces with NMR"
Evening Entertainment:
Lake Erie and Harbor Boat Trip, or
Cleveland Orchestra concert at Severance Hall
Sunday, May 14, 9.00am-12.00pm
• Session 4 : Challenging proteins
Chair: Jun Qin
- 9.00-9.40 Peter Wright (Scripps Inst.)
"New paradigms for molecular recognition: role of intrinsically disordered proteins in the regulation of transcription" - 9.45-10.10 Angela Gronenborn (Univ. Pittsburgh)
"NMR studies of large proteins and protein complexes" - 10.15-10.40 Mike Zagorski (CCSB)
"NMR Reveals Unique Metal Binding Motifs in the Abeta Peptide of Alzheimer's Disease"
Break (15 mins)
Chair: Mike Zagorski
- 11.00-11.25 Frank Sönnichsen (CCSB) "The juxtamembrane domain: regulator of Epidermal Growth Factor Receptor activation and sorting"
- 11.30-11.55 Charles Sanders ( Vanderbilt Univ. )
"Preliminary NMR Structure of Diacylglycerol Kinase, An Integral Membrane Protein" - 12.00-12.25 Tom Gerken
" Understanding Protein O-Glycosylation: Carbon 13 NMR and Edman Sequencing Studies of Mucin Type O-linked Glycoproteins"
12.30 Closing remarks,
Bus/Car to new CCSB facility building & light reception
